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. 2020 Jun 12;10:9531. doi: 10.1038/s41598-020-65737-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fundus photographs and fundus autofluorescence images from 18 patients with CRX-associated retinal disorder (CRX-RD). Fundus photographs and fundus autofluorescence (FAF) images demonstrate macular atrophy in nine subjects (Patients 1, 3–6, 8, 15, 17, 18) and slight atrophic changes at the macula in three subjects (Patients 7, 11, 12). Peripheral atrophy is observed in four subjects (Patients 5, 13, 14, 16; detected by fundoscopy in Patients 5 and 14). Atrophic changes affecting the entire retina, including the macula, mid-periphery, and periphery are found in Patient 5. Macular atrophy is more evident on FAF images in eight subjects (Patients 1, 3, 8, 11, 12, 15, 17, 18). A ring of high density AF is observed in 11 subjects to various degrees (Patients 1, 2, 3, 7, 8, 11–13, 15, 17, 18). Foveal appearance is relatively preserved in nine subjects (Patients 1–3, 7, 10–12, 16, 17).