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. 2020 Jun 12;10:9531. doi: 10.1038/s41598-020-65737-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spectral-domain optical coherence tomographic images from 18 patients with CRX-RD. Spectral-domain optical coherence tomographic images demonstrate outer retinal disruption at the macula in eight subjects (Patients 1, 3, 4–6, 8, 15, 18). Outer retinal disruption at the peri-macula is observed in 12 subjects (Patients 1–6, 8, 13–15, 17, 18). Intraretinal micro-cystic changes are noted in Patient 13. Epiretinal membrane is found in Patient 8. Marked preservation of the photoreceptor ellipsoid zone (EZ) line at the fovea is identified in eight subjects (Patients 2, 5, 7, 10–14), and slightly preserved EZ at the fovea isobserved in three subjects (Patients 9, 16, 17). Preserved foveal structure surrounded by parafoveal atrophy (i.e., bull’s eye pattern) is found in six subjects (Patients 1, 2, 10, 11, 12, 17).