Fig. 5. p-IKKβ scarcity partially reversed liver damage derived from CRYAB reduction after ischemia for 1 h followed by 6-h reperfusion.

a Hepatic pathologic alteration in mouse liver after inhibition of CRYAB or IKKβ. Scale bar = 200 μm. b Assessment of hepatic apoptosis by TUNEL. Scale bar = 200 μm. c Levels of IL-6, IL-1β, and TNF-α in mouse serum. d Levels of AST and ALT in mouse serum. IMD 0354-, CRYAB shRNA-, and the IRI group was settled as sham group. n = 5 for each group, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.