Figure 4.

Comparison of the genomic instability scores and the expressions of immune checkpoint genes between immune subtypes in 7 cancer types. (a), Comparison of the sCNV burden, measured by the log₁₀-transformed total number of segments in each sample’s copy number profile between the subtypes across 7 cancer types. (b), Comparison of the log₁₀-transformed the number of nonsynonymous mutations per Mb in the genome between the subtypes across 7 cancer types. (c), Heatmaps of the log₂-transformed expression levels (TPM) of 10 immune checkpoint genes between the subtypes across 7 cancer types. (d), RNA expressions (TPM) of four immune checkpoint genes in immune-deficient and immune-competent subtypes across 7 cancers. The level of significance denoted as: ns., non-significant, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. Statistical significances of the genomic instability scores and the expression of the genes between subtypes were measured by unpaired Student t test.