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. 2020 Jun 9;14:2263–2274. doi: 10.2147/DDDT.S241291

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© 2020 Hong et al.

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The viability of A549 cells (A), NCI-H1299 cells (B), and BEAS-2B cells (C) when incubated with CDDP-PLGA/CUR LBL NPs, CDDP/CUR LBL NPs, CDDP LBL NPs, CUR LBL NPs, LBL NPs, free CDDP/CUR, free CDDP and free CUR in different concentrations for 72 h. In vitro cytotoxicity of LBL NPs on A549 cells was assessed by the MTT assay. Data presented as mean ± SD, n = 6. *means P < 0.05.

Abbreviations: NSCLC, non-small cell lung cancer; CDDP, cisplatin; CUR, curcumin; LBL, layer-by-layer; NPs, lipid-polymer hybrid nanoparticles; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide.