Table 2.

Grade 3/4 Adverse Events

	Cabozantinib	Regorafenib	Ramucirumab
Fatigue	17%	9%	7%
Palmar plantar erythrodysesthesia	17%	13%	0%
Hypertension	16%	15%	12.7%
Diarrhea	10%	3%	1%
Decreased appetite	6%	3%	1%
Other			Bleeding 5%

Note: Data from these studies.^5–7