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. 2020 Jun 2;12:4129–4137. doi: 10.2147/CMAR.S252185

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© 2020 Zhang et al.

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miR-100-5p suppressed the invasion and migration of chordoma cells. (A and B) Wound-healing assays were performed in chordoma cells transfected with miR-100-5p mimics or negative controls. (C and D) Transwell assays showed that migration and invasion ability of chordoma cells can be attenuated significantly by miR-100-5p mimics. (magnification 100X). (E and F) The mRNA and protein expression levels of E-cadherin, N-cadherin, and vimentin in chordoma cells transfected with miR-100-5p mimics or negative control were measured by qRT-PCR and Western blotting separately. (G) IHC results showed that miR-100-5p increased the expression of E-cadherin and decreased the expression of vimentin and N-cadherin in tumors formed by chordoma cells. All experiments were repeated three times. Data are presented as the mean ± S.D. *P < 0.05, **P < 0.01.