Table 2.
Characteristics of Examined KL SNPs and Methylation Loci
| SNPs |
Methylation Loci |
|||||
|---|---|---|---|---|---|---|
| Variable | MAF | Minor/Major Allele | Location (bp) | Mean (M values) | SD (M values) | Range (raw beta values) |
| SNPs | ||||||
| rs398655 | 40.71 | C/A | 33587652 | |||
| rs9527025 | 17.15 | C/G | 33628193 | |||
| rs9315202 | 25.64 | A/G | 33642016 | |||
| Methylation | ||||||
| cg00129557 | −3.70 | .77 | .22 | |||
| cg02706658 | −3.33 | .63 | .23 | |||
| cg09886946 | −3.03 | .38 | .13 | |||
| cg17806623 | −2.64 | .27 | .12 | |||
| cg18056695 | −3.61 | .46 | .14 | |||
| cg19154940 | 3.53 | .49 | .14 | |||
| cg20672059 | 2.48 | .23 | .11 | |||
| cg23584087 | 3.91 | .64 | .15 | |||
| cg25223823 | 2.56 | .40 | .22 | |||
| cg26325430 | 4.06 | .58 | .12 | |||
Note. M values (log 2 logit transformed beta-values) were analyzed in this study. The raw beta range (proportion of methylated DNA) is presented in this table as this was used to exclude loci with insufficient variability. All SNPs examined were located on chromosome 13 and the base pair location is referenced to the GRCH37.p13 build. The MAF of each SNP was consistent with that reported for the CEU reference sample in 1000 Genomes. SNPs = single nucleotide polymorphism; bp = base pair; MAF = minor allele frequency; SD = standard deviation.