. Author manuscript; available in PMC: 2020 Jun 14.

Published in final edited form as: Mult Scler. 2020 Apr 16;26(7):843–854. doi: 10.1177/1352458519900942

Table 2.

Baseline retinal layer thicknesses and comparisons between groups. Statistically significant results are in bold

	Retinal layer thicknesses, μm; mean (SD)				p-value^a (unadjusted)			p-value^a (adjusted^b)
	Underweight [BMI <18.5 kg/m²] (n=18 eyes)	Normal weight [BMI 18.5- 24.9 kg/m²] (n=401 eyes)	Overweight [BMI 25-29.9 kg/m²] (n=289 eyes)	Obese [BMI ≥30 kg/m²] (n=264 eyes)	Normal vs. overweight	Normal vs. obese	Overweight vs. obese	Normal vs. overweight	Normal vs. obese	Overweight vs. obese
GCIPL	65.3 (9.6)	68.6 (9.1)	70.6 (8.7)	70.2 (8.6)	0.023	0.046	0.82	0.018	0.021	0.99
INL	44.8 (2.6)	44.5 (2.8)	44.9 (3.0)	44.6 (3.2)	0.19	0.61	0.46	0.23	0.47	0.66
ONL	68.7 (7.0)	67.1 (5.6)	68.2 (5.7)	67.3 (5.6)	0.051	0.5	0.25	0.17	0.5	0.54
pRNFL	81.0 (15.2)	84.3 (12.7)	86.5 (12.4)	86.7 (13.5)	0.08	0.06	0.91	0.05	0.058	0.97

Derived from mixed effects linear regression models, accounting for within subject inter-eye correlations. P-values are for group comparisons between the normal weight, overweight and obese cohorts. Data from 9 MS patients who were underweight (BMI <18.5 kg/m²) are provided for descriptive reasons but are not included in analyses due to insufficient sample size.

Multivariable mixed-effects linear regression models including age, sex, race, MS subtype, ON history

BMI: body mass index; MS: multiple sclerosis; ON: optic neuritis; GCIPL: ganglion cell + inner plexiform layer; INL: inner nuclear layer; ONL: outer nuclear layer; pRNFL: peri-papillary retinal nerve fiber layer