. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2020 Apr 22;47(3):199–218. doi: 10.1007/s10928-020-09684-2

Table 1.

Theoretical compound physico-chemistry and ADME information [12]

Physico-chemistry	LogP	2.5
	pKa	NA (neutral)
	MW	350 g/mol (0 halogens)
ADME	Fup	0.1
	Binding protein	albumin
	CLint,3A4 (hepatic)	0.25 1/min/umol CYP3A4

CLint,3A4, intrinsic clearance intrinsic clearance of (hepatic) isozyme CYP3A4; fup, plasma fraction unbound; LogP, logarithm of the octanol-water partition coefficient (lipophilicity); MW, molecular weight; pKa, negative logarithm of the acid dissociation constant; NA, not applicable