Table 4.
Conventional model evaluation metrics for the positive and negative-control simulation studies
| Variable | Positive-control study | Negative-control study |
|---|---|---|
| Number of subjects | 10 | 10 |
| Samples per Subject | 6 | 6 |
| Total Samples | 60 | 60 |
| ME (mg/L) | 0.025 | −0.207 |
| RMSE (mg/L) | 0.445 | 0.472 |
| AFE | 1.08 | 1.26 |
| AAFE | 1.34 | 1.39 |
| Number of samples outside the model’s 90 PI (N [%]) | 16 (26.67%)* | 19 (31.67%)* |
ME, mean error; RMSE, root mean squared error; AFE, average fold-error ; AAFE, absolute average fold-error ; PI, prediction interval; PK, pharmacokinetic
*
Proportion of observed data exceeding model’s 90% PI is statistically greater than 0.10 (p-value<0.05, exact binomial test)