FIGURE 2.

Proteomics profiling of extracellular vesicles (EVs) isolated from Alzheimer's disease (AD) and control (CTRL) brains: A, Venn diagram representing the number of EV proteins differentially identified in CTRL and AD. B, Gene ontology (GO) analysis using DAVID Bioinformatics Resources 6.8. The GO term of Top 5 Cellular Component with ‐log₁₀ (FDR P‐value). C, The GO term of Top 5 Pathway Ontology with ‐log₁₀ (FDR ‐value). D, Sequence coverage of identified tryptic fragment peptide from AD‐related protein (tau, APP, SNCA, APOE) in AD group by LC‐MS/MS analysis. Identified peptides and phosphorylation sites are shown in black and red bold, respectively. E, KEGG pathway of AD. The 68 proteins identified in the AD group are highlighted by red stars