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. 2020 Feb 12;267(6):1603–1612. doi: 10.1007/s00415-020-09738-y

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© The Author(s) 2020, corrected publication 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Within-individual trajectories of cognitive decline on seven cognitive domains. NPA neuropsychological assessment, MAPT microtubule-associated protein tau, GRN progranulin, C9orf72 chromosome 9 open reading frame 72. Raw data for each neuropsychological test were first converted to z-scores by standardization to the baseline data of non-carriers. Composite cognitive domain scores were calculated. Each subplot presents the trajectory on a specific cognitive domain. Data are available in: language (MAPTn = 9; GRNn = 3; C9orf72n = 8); attention and mental processing speed (MAPTn = 8; GRNn = 3; C9orf72n = 8); executive functioning (MAPTn = 9; GRNn = 2; C9orf72n = 8); working memory (MAPTn = 5; GRNn = 2; C9orf72n = 6); memory learning (MAPT n = 7; GRNn = 3; C9orf72n = 8); memory recall (MAPTn = 7; GRNn = 3; C9orf72n = 7); visuoconstruction (MAPTn = 6; GRNn = 2; C9orf72n = 7)