Fig. 1.

Selective depletion of AhR in langerin-expressing cells. Vertical sections of back skin from B6, AhR-loxP, and Langerin-AhR^−/− mice were stained with AhR-FITC and CD207-PE (or corresponding isotype antibodies) along with a nuclear DAPI staining. The result showed the uniform expression of AhR in the epidermis of all three strains and dendritic appearance of CD207-expressing cells in B6 and AhR-loxP mice. However, there was a reduction of CD207-expressing cells in the Langerin-AhR^−/− mice (representative photos of one out of three independent experiments with n = 5 mice each are depicted).