Table 2.
Hazard ratios and 95% confidence intervals for the incidence of hospitalization for heart failure according to the eight groups of transition in obesity sub-phenotypes
| 1st examination (2009-2010) | 2nd examination (2013-2014) | n | Events (n) | Follow-up duration (person-years) | Incidence rate (per 1000 person-years) | Hazard ratios (95% confidence intervals) | ||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||||
| MHNO | MHNO | 4,284,989 | 1511 | 15,849,397.29 | 0.09533 | 1 (ref.) | 1 (ref.) | 1 (ref.) |
| MHO | 420,879 | 120 | 1,535,416.61 | 0.07815 | 0.831 (0.690, 1.001) | 1.116 (0.926, 1.345) | 1.096 (0.909, 1.321) | |
| MUNO | 546,422 | 581 | 2,049,295.01 | 0.28351 | 2.916 (2.649, 3.209) | 1.803 (1.637, 1.986) | 1.481 (1.341, 1.635) | |
| MUO | 167,760 | 105 | 615,952.83 | 0.17047 | 1.792 (1.470, 2.184) | 1.548 (1.269, 1.887) | 1.283 (1.051, 1.566) | |
| MHO | MHNO | 252,858 | 99 | 936,371.35 | 0.10573 | 1.108 (0.904, 1.357) | 0.610 (0.491, 0.758) | 0.665 (0.537,0.824) |
| MHO | 891,470 | 318 | 3,280,816.52 | 0.09693 | 1.022 (0.905, 1.153) | 1.173 (1.039, 1.325) | 1.132 (1.002, 1.280) | |
| MUNO | 51,148 | 63 | 192,110.25 | 0.32794 | 3.366 (2.616, 4.331) | 2.033 (1.579, 2.616) | 1.674 (1.299, 2.156) | |
| MUO | 533,237 | 354 | 1,964,558.09 | 0.18019 | 1.891 (1.684, 2.123) | 1.677 (1.493, 1.884) | 1.385 (1.230, 1.560) | |
Model 1: unadjusted
Model 2: adjusted for age, sex, smoking history, alcohol consumption, regular exercise, and eGFR
Model 3: adjusted for model 2 + systolic BP, LDL-C, and household income
MHNO metabolically healthy non-obesity, MHO metabolically healthy obesity, MUNO metabolically unhealthy non-obesity, MUO metabolically unhealthy obesity, BP blood pressure, LDL-C low-density lipoprotein cholesterol