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. 2020 Jun 13;18:127. doi: 10.1186/s12957-020-01891-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — OATP1B3 mRNA and protein expression in HCC tissue and adjacent nontumorous tissues. a Relative expression of OATP1B3 was detected by qRT-PCR. OATP1B3 mRNA was higher in matched adjacent nontumorous tissue (ANT) than in HCC tissue (T) (n = 30). Relative mRNA expression in the ANT group showed abnormal distribution; thus, the Wilcoxon signed-rank test was applied, and the data are represented as the median ± interquartile range. b OATP1B3 mRNA expression levels in 8 pairs of Ts and ANTs were compared. Error bars represent the SD. c Relative expression of OATP1B3 protein was detected by Western blotting. OATP1B3 expression in T was significantly lower than that in ANT (n = 34). The data are represented as the mean ± SD, and the paired Student’s t test was applied. d Representative Western blot of OATP1B3 in T and ANT in 8 pairs of samples. Β-Actin was used as an endogenous control. ^aP < 0.05