Table 1.
Characteristics by LBD subtype and Braak NFT stage
| LBD subtype |
Braak NFT group |
||||||
|---|---|---|---|---|---|---|---|
| DLBD | TLBD | P-value | Low stage I–II | Medium stage III–IV | High stage V–VI | P-value | |
| N | 26 | 8 | 10 | 17 | 7 | ||
| Age (years), mean (SD) | 72.7 (6.2) | 74.6 (9.3) | 0.49 | 72.0 (6.9) | 74.3 (7.2) | 71.9 (6.9) | 0.63 |
| Male, n (%) | 18 (69) | 7 (88) | 0.31 | 10 (100) | 12 (71) | 3 (43) | 0.029 |
| APOE ϵ4 allele, n (%) | 17 (65.4) | 3 (37.5) | 0.16 | 5 (50.0) | 8 (47.1) | 7 (100.0) | 0.045 |
| Years from imaging to death, mean (SD) | 2.7 (1.5) | 2.1 (1.4) | 0.36 | 2.5 (1.1) | 2.3 (1.4) | 3.1 (2.0) | 0.43 |
| MMSE, mean (SD) | 17.3 (6.8) | 22.4 (4.4) | 0.06 | 21.3 (5.4) | 17.9 (6.3) | 16.1 (8.3) | 0.26 |
| CDR sum of boxes, mean (SD) | 8.3 (4.7) | 4.5 (2.2) | 0.036 | 5.0 (3.1) | 8.6 (4.7) | 8.0 (5.0) | 0.12 |
| FDG CIS ratio, mean (SD) | 1.07 (0.12) | 1.11 (0.09) | 0.42 | 1.15 (0.12) | 1.07 (0.07) | 0.98 (0.13) | 0.008 |
| FDG occipital, SUVR, mean (SD) | 1.27 (0.19) | 1.34 (0.16) | 0.38 | 1.27 (0.19) | 1.28 (0.21) | 1.33 (0.10) | 0.78 |
| Vis. hallucinations, n (%) | 16 (67) | 4 (67) | 1.00 | 6 (67) | 11 (73) | 3 (50) | 0.59 |
| Fluctuations, n (%) | 17 (71) | 4 (67) | 0.84 | 7 (78) | 11 (73) | 3 (50) | 0.48 |
| Parkinsonism, n (%) | 17 (71) | 6 (100) | 0.13 | 9 (100) | 12 (80) | 2 (33) | 0.010 |
| Probable RBD, n (%) | 19 (79) | 6 (100) | 0.22 | 9 (100) | 13 (87) | 3 (50) | 0.035 |
CIS = cingulate island sign; DLBD = diffuse Lewy body disease; SD = standard deviation; SUVR = standardized uptake value ratio; TLBD = transitional Lewy body disease.