Table 2.
Comparison of Pediatric MLung to Current Devices in Clinical Use and Next Generation Devices in the Literature
| Comparison Between MLung and Commercial Oxygenators | ||||||
|---|---|---|---|---|---|---|
| Device | Surface Area (m2) | Rated Flow (L/min) | Pressure Drop at Rated Flow (mm Hg) | Priming Volume (mL) | Gas Exchange Efficiency at Rated Flow (mL/min/m2) | |
| O2 | CO2 | |||||
| Terumo Capiox RX05 (Terumo Cardiovascular Group, Ann Arbor, Michigan) | 0.5 | 1.5 | 110 | 43 | 150 | 500* |
| Maquet Quadrox Neonatal (Maquet, Rastatt, Germany) | 0.38 | 1.5 | 58 | 40 | 197 | 189 |
| Maquet Quadrox Pediatric (Maquet, Rastatt, Germany) | 0.8 | 2.8 | 60 (1.5 L/min) | 99 | 175 | 250 |
| Sorin Dideco D100 (Sorin Group, Saluggia, Italy) | 0.22 | 0.7 | 175 | 47 | 159 | 145 |
| Novalung ILA (Xenios AG, Heilbronn, Germany) | 1.3 | Data not available† | Data not available | 175 | 85† | 212† |
| Pedipump Lung (University of Maryland, Baltimore, Maryland) | 0.3 | 2.5 | 150 | 110 | 400 | 343‡ |
| P-PAL (University of Pittsburgh, Pittsburgh, Pennsylvania) | 0.3 | Data not available§ | Data not available§ | 270§ | 310§ | Data not available |
| MLung (single inlet); (University of Michigan, Ann Arbor, Michigan) | 0.28 | 2.0 | 106 | 47 | 357 | 714 |
| Pediatric MLung (University of Michigan, Ann Arbor, Michigan) | 0.13 | 1.0 | 25 | 68 ± 7 | 349 | 343 ± 90¶ |
Data for commercial devices were gathered from manufacturers technical information available via company websites.
Capiox RX05 CO2 removal data were estimated from Sun et al.32
Novalung iLA is designed for CO2 removal, and data at rated flow were not available; therefore, the CO2 removal at the maximum flow for which data were available was reported.
CO2 exchange efficiency for the Pedipump Lung was estimated from Wei et al.33
Rated flow was not reported for the P-PAL; however, gas exchange efficiency was comparable to the PediPL at a flow rate of 2 L/min.33,34 Priming volume of the P-PAL circuit is reported which includes fiber bundle area, pump area, and conduits.35 Pressure drop of gas exchange region not reported; this device incorporates a pump to generate pressure and is intended for venoarterial use. CO2 removal data not reported.
CO2 exchange efficiency was taken as the average of the highest values achieved during in vivo testing (n = 3).
CO2, carbon dioxide; O2, oxygen.