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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: J Am Chem Soc. 2020 Apr 3;142(15):6951–6956. doi: 10.1021/jacs.0c02665

Figure 1.

Figure 1.

A) Head-to-tail and tail-to-head cyclization reactions. B) Schematic illustrating Nature’s strategy for controlled ionization-dependent cyclizations. C) Proposed strategy for enantioselective tail-to-head cyclizations catalyzed by chiral hydrogen-bond donors.