Analysis of Different Methods to Adjust for Blood Pressure Treatment in the Relationship Between Systolic Blood Pressure And Diabetes in the American Indian Study.

	1993–1997		1998–2002		2003–2007
	Beta coefficient or odds ratio	95% CI	Beta coefficient or odds ratio	95% CI	Beta coefficient or odds ratio	95% CI	P value*
Men	n=1035		n=1019		n=1432
No adjustment	3.86	1.55, 6.17	3.65	1.34, 5.95	4.47	2.37, 6.57	0.37
Treatment as covariate	2.04	−0.31, 4.39	2.32	−0.08, 4.73	3.76	1.50, 6.02	0.15
Fixed effect (+15 mmHg)	6.77	4.24, 9.31	7.32	4.83, 9.81	9.30	7.08, 11.52	0.49
Non-parametric adjustment	9.78	6.72, 12.84	10.32	7.45, 13.19	14.04	11.50, 16.57	0.04
Censored normal regression	6.89	4.32, 9.45	8.24	5.65, 10.82	12.09	9.62, 14.55	0.01
HypertensionϮ	2.78	2.01, 3.85	2.92	2.11, 4.02	4.50	3.46, 5.84	0.02
Women	n=1672		n=1631		n=2140
No adjustment	5.82	4.04, 7.60	4.00	2.25, 5.75	2.17	0.67, 3.68	<0.001
Treatment as covariate	4.54	2.80, 6.29	2.27	0.47, 4.07	0.83	−0.75, 2.42	<0.001
Fixed effect (+15 mmHg)	7.28	5.31, 9.24	7.40	5.48, 9.32	6.56	4.92, 8.20	0.02
Non-parametric adjustment	10.17	7.74, 12.59	10.97	8.83, 13.12	14.07	12.11, 16.03	0.06
Censored normal regression	6.96	5.03, 8.89	7.89	5.92, 9.85	8.33	6.54, 10.12	0.47
HypertensionϮ	3.50	2.47, 4.95	4.41	3.28, 5.94	5.51	4.28, 7.09	0.01

Analyses were adjusted for age. Beta coefficients are difference in systolic blood pressure (mmHg) between those with diabetes compared to without diabetes.

^ϮResults are odds ratio (95% CI).

^*P value for interaction between diabetes and time.