Figure 2.

(A) Physiologic musculoskeletal health results in effective muscle and fracture repair (yellow arrows). (B) Pathologic musculoskeletal repair may result in poor fracture repair, including fracture nonunion (yellow arrows), and poor muscle repair, including bone formation in muscle (heterotopic ossification‐red arrows). Physiologic maintenance of musculoskeletal organs promotes healthy bone (C) and joints (E), while pathologic musculoskeletal maintenance and inflammation provoke degenerative disease, including significant bone loss (osteoporosis) (D) and arthritis (F). Images shown are from healthy and diseased mouse tissues