Figure 3.

In chronic inflammatory conditions and aging, microinjuries sustained during daily movement trigger a persistent APR cycle in which fibrin deposition and plasmin activation are dysregulated in musculoskeletal tissues. The consequence of this cyclical acute‐phase response (APR) is chronic inflammation, inappropriate tissue remodeling, and ultimately, degeneration of the musculoskeletal tissues. Recurring fibrin deposition and inflammation positively feedback upon one another (black arrow), furthering tissue degeneration