TABLE 3.
Significant Predictors of Overall and Progression-Free Survival
| Outcome | Predictor | Hazard ratio | 95% CI | P value |
|---|---|---|---|---|
| Overall survival | MGMT methylation | 0.15 | 0.04-0.52 | .003 |
| Dose to the whole brain | 1.1/Gy | 1.02-1.19 | .01 | |
| Age | 1.04/yr | 1.003-1.07 | .03 | |
| Change in processing speed (coding) | 0.83 | 0.73-0.94 | .003 | |
| Change processing speed (Trails A) | 1.02 | 1.002-1.03 | .03 | |
| Change in verbal learning (HVLT-R Total Recall) | 0.80 | 0.66-0.97 | .02 | |
| Progression-free survival | MGMT methylation | 0.16 | 0.04-0.59 | .006 |
| Dose to the whole brain | 1.07/Gy | 1.002-1.14 | .04 | |
| Age | 1.03/yr | 1.000-1.06 | .049 |
Hazard ratios, 95% CIs, and p-values are obtained from univariate Cox regression.