Skip to main content
. Author manuscript; available in PMC: 2021 Aug 15.
Published in final edited form as: Neuropharmacology. 2020 Jan 25;173:107971. doi: 10.1016/j.neuropharm.2020.107971

Figure 1. Effects of PTC-174 on recombinant NMDA receptor subtypes.

Figure 1.

A) Chemical structure of PTC-174. B) Representative recordings of pharmacological evaluation of PTC-174 measured using two-electrode voltage-clamp electrophysiology at recombinant diheteromeric and triheteromeric NMDA receptor subtypes. The receptors were activated by maximally efficacious concentrations of glutamate plus glycine (100 μM and 50 μM, respectively) followed by increasing concentrations of PTC-174. Vertical scale bars indicate 500 nA and vertical scale bar indicates 2 min. Responses to glutamate plus glycine alone are indicated by 1x. C-E) PTC-174 concentration-response data at recombinant NMDA receptor subtypes. Responses to glutamate plus glycine alone was defined as 100% (control) and the responses to incremental additions of PTC-174 were expressed as a percentage of this value. Data are mean ± SEM from 6–16 oocytes. Note that for some data points, error bars are smaller than symbols (i.e. contained within the symbols). See Table 1 for potencies and maximal modulation.