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. Author manuscript; available in PMC: 2021 Aug 15.
Published in final edited form as: Neuropharmacology. 2020 Jan 25;173:107971. doi: 10.1016/j.neuropharm.2020.107971

Figure 2. Effects of PTC-174 and CIQ on glutamate and glycine potencies.

Figure 2.

A-D) Glutamate (A,C) and glycine (B,D) concentration-response data in the presence and absence of 10 μM PTC-174 (A,B) or 10 μM (+)-CIQ (C,D) were measured using two-electrode voltage-clamp electrophysiology at recombinant GluN1/2D receptors. Responses to maximal glutamate plus glycine alone was defined as 100% (control). E,F) Glutamate (E) and glycine (F) concentration-response data in the presence and absence of 10 μM PTC-174 were measured using two-electrode voltage-clamp electrophysiology at recombinant GluN1/2C receptors. Data are mean ± SEM from 5–8 oocytes. See Table 2 for EC50 values.