TABLE 1.

Self‐comparison of MMSE scores in AD and aMCI patients before and after hyperbaric oxygen treatment

	AD		aMCI
Time	Mean ± SD	P value	Mean ± SD	P value
Baseline	15.19 ± 7.55	–	27.00 ± 2.19	–
1‐month follow‐up	16.43 ± 8.21	0.005 *	28.00 ± 2.28	0.070
3‐month follow‐up	15.38 ± 8.05	0.750	28.45 ± 1.97	0.026 *
6‐month follow‐up	13.95 ± 7.63	0.056	27.82 ± 2.34	0.136

Data of MMSE scores in AD patients were analyzed by paired t test; data of MMSE scores in aMCI patients were analyzed by Wilcoxon signed‐rank test.

^* P < 0.05. Sample size: n = 42 in AD patients (n = 40 at 6‐month follow‐up); n = 11 in aMCI patients. The P values of 1‐, 3‐, and 6‐month follow‐up were compared with the baseline level.

Abbreviations: AD, Alzheimer's disease: aMCI, amnestic mild cognitive impairment; MMSE, Mini‐Mental State Examination; SD, standard deviation