Table 2.
Tumor Weight Resulting from Different Treatment Modalities and Applied Doses
| BTB14431 |
Emodin |
Control | |||||||
|---|---|---|---|---|---|---|---|---|---|
| iv treatment | 0.3 mg/kg | I | 1.7 mg/kg | II | 2.5 mg/kg | III | 5 mg/kg | IV | V |
| sc tumor weight (g) | 2.5 (1.7 – 3.1) p = 0.035 |
3.7 (3.2 – 4.1) p = 0.604 |
2.2 (1.4 – 2.6) p ≤ 0.01 |
2.2 (1.5 – 2.7) p = 0.023 |
4.2 (3 – 4.7) |
||||
| ip tumor weight (g) | 4.5 (3.3 – 5.4) p ≤ 0.01 |
14.1 (12.7 – 16.8) p = 0.447 |
7.4 (6.3 – 8.3) p ≤ 0.01 |
6.4 (5.5 – 7.1) p ≤ 0.01 |
13.5 (11.1 – 15.8) |
||||
| Total tumor weight (g) | 6.8 (5.3 – 8.2) p ≤ 0.01 |
18.2 (16.0 – 20.8) p = 0.497 |
9.4 (7.9 – 10.7) p ≤ 0.01 |
8.3 (7.6 – 9.3) p ≤ 0.01 |
15.9 (14.5 - 20) |
||||
| ip treatment | 0,3 mg/kg | VI | 1,7 mg/kg | VII | 2,5 mg/kg | VIII | 5 mg/kg | IX | X |
| sc tumor weight (g) | 4.1 (2.7 – 4.8) p = 0.829 |
3.6 (2.5 – 4.7) p = 1.000 |
4.1 (3.2 - 5) p = 0.447 |
3.5 (2.8 – 4.7) p = 0.971 |
4.0 (2.6 – 4.5) |
||||
| ip tumor weight (g) | 9.0 (7.4 – 13.1) p = 0.055 |
11.8 (8.4 – 15.2) p = 0.156 |
11.3 (8.8 – 13.8) p = 0.079 |
8.6 (6 – 10.4) p ≤ 0.01 |
15.5 (12.1 – 19.5) |
||||
| Total tumor weight (g) | 13.3 (10.4 – 17.6) p = 0.101 |
14.3 (11.5 – 19.3) p = 0.243 |
15.8 (12.7 – 18.1) p = 0.243 |
11.1 (10.1 – 13.8) p ≤ 0.01 |
19.8 (15.4 – 23.3) |
||||
Subcutaneous (sc), intraperitoneal (ip) and overall median tumor weight at T3 after either intravenous (iv) or intraperitoneal (ip) treatment by varying doses of emodin, BTB14431 and electrolyte solution. Parentheses show the 90% confidence interval. P-value was obtained by Mann-Whitney-U-Test comparison against saline solution (control). Gray background color marks p values > 0.05.