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. 2020 Mar 13;41(10):2686–2701. doi: 10.1002/hbm.24971

Table 3.

Reduced diffusivities in mild and moderate to severe OSA groups compared with controls

Cluster size T Peak MNI coordinates Fiber type and white matter tracts (lobes or regions)
Panel (a) Reduced MD in mild OSA compared with controls

16,151

209

78

5.26

4.32

3.21

31

−30

−30

−46

−30

−18

16

2

9

 Projections

  • Bilateral corona radiata (cingulate, frontal, parietal, temporal)

  • Internal capsule (right anterior and posterior limb, bilateral retrolenticular)

  • Right cerebral peduncle

  • Bilateral posterior thalamic radiation
Association

  • Bilateral external capsule

  • Bilateral fornix

  • Stria terminalis

  • Left sagittal stratum

  • Right superior longitudinal fasciculus (frontal, temporal)

  • Left superior longitudinal fasciculus (frontal, parietal, temporal, occipital)

  • Left inferior longitudinal fasciculus (temporal)

Commissural

  • Left tapetum

  • Corpus callosum (splenium, body and genu)

Panel (b) Reduced RD in mild OSA compared with controls

595

2,919

37

21

4.91

4.45

4.04

4.05

18

−22

−28

−30

50

−82

−20

−30

−4

11

−7

2

 Projection

  • Bilateral corona radiata (cingulate, frontal, parietal, temporal)

  • Internal capsule (left retrolenticular)

  • Bilateral posterior thalamic radiation
Association

  • Left fornix

  • Stria terminalis

  • Right superior longitudinal fasciculus (parietal)

  • Left superior longitudinal fasciculus (parietal, temporal, occipital)

Commissural

  • Left tapetum

  • Corpus callosum (splenium, body and genu)

Panel (c) Reduced AD in mild OSA compared with controls
17,376 5.52 −28 −47 19 Projection

  • Bilateral corona radiata (anterior cingulate, frontal, parietal, temporal)

  • Internal capsule (bilateral anterior and posterior limb, bilateral retrolenticular)

  • Bilateral cerebral peduncle

  • Bilateral posterior thalamic radiation
Association

  • Bilateral external capsule

  • Right sagittal stratum

  • Right superior longitudinal fasciculus (frontal, parietal, temporal)

  • Left superior longitudinal fasciculus (frontal, temporal)

Commissural

  • Bilateral tapetum

  • Corpus callosum (splenium, body, and genu)

Panel (d) Reduced AD in moderate to severe OSA compared with controls
2,178 4.47 −5 1 26 Commissural

  • Body of the corpus callosum

Note: Group comparisons were adjusted for body mass index (BMI). Family‐wise error (FWE)‐corrected p < .05.

Abbreviations: AD, axial diffusivity; MD, mean diffusivity; MNI, Montreal Neurological Institute; OSA, obstructive sleep apnea; RD, radial diffusivity.