. 2020 Jun 9;12:137–150. doi: 10.2147/JEP.S248677

Table 3.

Effect of Solvent Fractions of Clutia abyssinica Leaf Extract on Body Weight, Change in Body Weight and Absolute and Relative Liver Weight of Mice Administered with CCl4

Group	Body Weight (g)		Change in Body Weight	Liver Weight (g)	Relative Liver Weight (%)
Group	Initial	Final	Change in Body Weight	Liver Weight (g)	Relative Liver Weight (%)
DW	32.33 ± 1.17	34.41 ± 0.63	2.08 ± 0.61	2.46 ± 0.19	7.14 ± 0.52
2%TW80	32.50 ± 1.09	34.62 ± 0.87	2.12 ± 0.52	2.40 ± 0.07	6.94 ± 0.14
CCl4	32.50 ± 0.89	29.34 ± 0.56^a**	−3.16 ± 0.66^a***	3.56 ± 0.21^a**	12.16 ± 0.76^a***
Silymarin + CCl4	32.00 ± 1.03	34.00 ± 0.89^b*	2.00 ± 0.37^b***	2.62 ± 0.19^b*	7.70 ± 0.52^b***
BF100 + CCl4	33.00 ± 0.82	30.80 ± 0.84^d*	−2.20 ± 0.37^a*^,c^,d^,e	3.36 ± 0.14^a*	10.89 ± 0.22^a*^,c^,d^,e
BF200 + CCl4	33.05 ± 1.01	34.92 ± 0.90^b**	1.87 ± 0.48^b***	2.91 ± 0.27	8.34 ± 0.76^b***
BF400 + CCl4	31.33 ± 0.67	33.27 ± 1.41	1.94 ± 1.20^b***	2.78 ± 0.24	8.37 ± 0.66^b***
CF100 + CCl4	31.67 ± 1.02	29.37 ± 0.98^a*^,c	−2.30 ± 0.32^a*^,c*	3.47 ± 0.29^a*	11.89 ± 1.09^a^,c
CF200 + CCl4	30.83 ± 0.79	28.61 ± 0.81^a*^,c	−2.22 ± 0.16^a*^,c*	3.62 ± 0.32^a*	12.63 ± 0.98^a*^,c
CF400 + CCl4	32.67 ± 0.99	31.52 ± 1.19	−1.15 ± 0.30^a**^,b^,c*	2.98 ± 0.28	9.41 ± 0.72
AF100 + CCl4	32.00 ± 1.55	29.66 ± 1.70^a*	−2.34 ± 0.4^a*^,c*	3.58 ± 0.34^a*	12.35 ± 1.58^a^,c
AF200 + CCl4	32.77 ± 1.20	30.29 ± 1.15	−2.47 ± 0.33^a*^,c*	3.43 ± 0.25^a*	11.38 ± 0.83^a*
AF400 + CCl4	32.83 ± 1.42	30.31 ± 1.32	−2.52 ± 0.22^a*^,c*	3.65 ± 0.26^a*^,c	12.04 ± 0.68^a*^,c

Notes: Each value represents mean ± S.E.M; n=6; ^aAgainst negative control; ^bAgainst CCl4; ^cAgainst standard (silymarin); ^dAgainst 200 mg/kg; ^eAgainst 400 mg/kg; *p < 0.05, **p < 0.01, ***p < 0.001.

Abbreviations: BF, n-butanol fraction; CF, chloroform fraction; AF, aqueous fraction; silymarin, silymarin 100 mg/kg; CCl4, carbon tetrachloride 2mL/kg; 2%TW80, 2% Tween 80 in water; DW, distilled water.