. 2020 Jun 9;12:137–150. doi: 10.2147/JEP.S248677

Table 4.

Effect of 80% Methanol Extract of the Leaves of Clutia abyssinica on Liver Function and Liver Chemistry of Mice Administered with CCl4

Group	AST (IU/L)	ALT (IU/L)	ALP (IU/L)	Total Protein (g/dL)	Albumin (mg/dL)	Bilirubin (mg/dL)
2%TW80	85.22 ± 2.53	94.02 ± 2.62	150.43 ± 3.61	5.11 ± 0.47	2.35 ± 0.14	1.18 ± 0.22
CCl4	210.38 ± 8.17^a***	221.57 ± 7.40^a***	353.61 ± 8.48^a***	3.21 ± 0.29^a**	1.28 ± 0.18^a*	3.83 ± 0.41^a***
Silymarin + CCl4	90.95 ± 2.85 (95.4)^b***	96.29 ± 3.29 (98.2)^b***	154.87 ± 4.32 (97.8)^b***	5.08 ± 0.18^b*	2.32 ± 0.27^b*	1.21 ± 0.21^b***
Me100 + CCl4	198.82 ± 5.21 (9.2)^a*^,c^,d^,e*	210.71 ± 3.88 (8.5)^a*^,c^,d^,e*	336.03 ± 4.80 (8.7)^a*^,c^,d^,e*	3.78 ± 0.37	1.68 ± 0.23	3.79 ± 0.32^a*^,c^,d^,e*
Me200 + CCl4	115.63 ± 4.29 (75.7)^a^,b^,c	120.46 ± 2.36 (79.3)^a^,b^,c*	192.53 ± 3.69 (79.3)^a*^,b^,c*^,e	4.86 ± 0.31^b*	2.23 ± 0.22	1.26 ± 0.34^b***
Me400 + CCl4	97.25 ± 3.23 (90.4)^b***	104.57 ± 3.26 (91.7)^b***	166.78 ± 4.16 (92)^b**^,d	5.06 ± 0.44^b*	2.28 ± 0.28^b*	1.23 ± 0.19^b***

Notes: Each value represents mean ± S.E.M; n=6; ^aAgainst 2%TW80; ^bAgainst CCl4; ^cAgainst standard (silymarin); ^dAgainst Me200 + CCl4; ^eAgainst Me400 + CCl4; *p < 0.05, **p < 0.01, ***p < 0.001.

Abbreviations: Me100, 80% methanol extract 100 mg/kg; Me200, 80% methanol extract 200 mg/kg; Me400, 80% methanol extract 400 mg/kg; silymarin, silymarin 100 mg/kg; CCl4, carbon tetrachloride 2mL/kg; 2%TW80, 2% Tween 80 in water.