. 2020 Jun 9;12:137–150. doi: 10.2147/JEP.S248677

Table 5.

Effect of Solvent Fractions of Clutia abyssinica Leaf Extract on Liver Function and Liver Chemistry of Mice Administered with CCl4

Group	AST (IU/L)	ALT (IU/L)	ALP (IU/L)	Total Protein (g/dL)	Albumin (mg/dL)	Bilirubin (mg/dL)
DW	84.43 ± 3.45	93.62 ± 2.54	148.84 ± 2.66	5.17 ± 0.32	2.40 ± 0.18	1.14 ± 0.20
2%TW80	85.22 ± 2.53	94.02 ± 2.62	150.43 ± 3.61	5.11 ± 0.47	2.35 ± 0.14	1.18 ± 0.22
CCl4	210.38 ± 8.17^a***	221.57 ± 7.40^a***	353.61 ± 8.48^a***	3.21 ± 0.29^a**	1.28 ± 0.18^a*	3.83 ± 0.41^a***
Silymarin + CCl4	90.95 ± 2.85 (95.4)^b***	96.29 ± 3.29 (98.2)^b***	154.87 ± 4.32 (97.8)^b***	5.08 ± 0.18^b*	2.32 ± 0.27^b*	1.21 ± 0.21^b***
BF100 + CCl4	202.74 ± 5.19 (6.1)^a*^,c^,d^,e*	214.53 ± 4.36 (5.5)^a*^,c^,d^,e*	342.54 ± 8.12 (5.4)^a*^,c^,d^,e*	3.69 ± 0.38	1.63 ± 0.36	3.86 ± 0.32^a*^,c^,d^,e*
BF200 + CCl4	121.42 ± 4.17 (71.1)^a*^,b^,c*	125.23 ± 3.96 (75.5)^a*^,b^,c**	200.82 ± 4.48 (75.2)^a*^,b^,c*^,e	4.46 ± 0.50	2.14 ± 0.14	1.58 ± 0.28^b***
BF400 + CCl4	111.38 ± 2.75 (79.1)^a^,b^,c	108.61 ± 2.57 (88.6)^b***	172.63 ± 3.11 (89.1)^b**^,d	4.96 ± 0.48^b*	2.30 ± 0.37	1.22 ± 0.30^b***
CF100 + CCl4	207.06 ± 6.83 (2.7)^a*^,c^,e**	223.62 ± 5.46 (−1.6)^a*^,c^,e**	356.22 ± 7.14 (−1.3)^a*^,c^,e**	3.37 ± 0.42^a^,c	1.52 ± 0.48	3.74 ± 0.51^a*^,c^,e*
CF200 + CCl4	197.87 ± 4.60 (10)^a*^,c^,e**	213.14 ± 4.51 (6.6)^a*^,c^,e**	340.34 ± 5.63 (6.5)^a*^,c^,e**	3.41 ± 0.45^a*	1.66 ± 0.47	3.43 ± 0.48^a^,c^,e*
CF400 + CCl4	127.18 ± 3.25 (66.5)^a*^,b^,c^,d*	133.28 ± 3.47 (69.2)^a*^,b^,c^,d*	213.63 ± 3.92 (68.9)^a*^,b^,c^,d*	4.72 ± 0.43	2.18 ± 0.44	1.61 ± 0.19^b*^,d
AF100 + CCl4	211.93 ± 4.53 (−1.2)^a*^,c*	222.47 ± 4.76 (−0.7)^a*^,c*	355.54 ± 7.93 (−0.9)^a*^,c*	3.18 ± 0.39^a^,c	1.38 ± 0.34	3.77 ± 0.63^a*^,c^,e*
AF200 + CCl4	208.68 ± 4.12 (1.3)^a*^,c*	214.75 ± 3.87 (5.3)^a*^,c*	346.98 ± 6.43 (3.2)^a*^,c*	3.31 ± 0.29^a^,c	1.42 ± 0.28	3.68 ± 0.42^a*^,c^,e*
AF400 + CCl4	202.19 ± 7.41 (6.5)^a*^,c*	207.37 ± 7.76 (11.1)^a*^,c*	343.83 ± 7.53 (4.8)^a*^,c*	3.25 ± 0.38^a^,c	1.26 ± 0.32	± 0.66^b*^,d*

Notes: Each value represents mean ± S.E.M; n=6; ^aAgainst negative control; ^bAgainst CCl4; ^cAgainst standard (silymarin); ^dAgainst 200 mg/kg; ^eAgainst 400 mg/kg; *p < 0.05, **p < 0.01, ***p < 0.001.

Abbreviations: BF, n-butanol fraction; CF, chloroform fraction; AF, aqueous fraction; silymarin, silymarin 100 mg/kg; CCl4, carbon tetrachloride 2mL/kg; 2%TW80, 2% Tween 80 in water; DW, distilled water.