FIGURE 3.

ALKBH5 significantly promoted ovarian carcinogenesis in vivo, after co‐culture of ovarian cancer cells with M2 macrophages. The co‐cultured ovarian cancer cells were subcutaneously inoculated into nude mice (n = 3) in each groups. The tumour volume formed under the skin of ovarian cancer cell lines with M2 co‐cultured group is significantly larger than that of M1 co‐cultured group. The size of tumour formed in the subcutaneous implantation mice model is monitored every 2 days. IHC indicates the overexpression of NANOG, SOX‐2 and OCT‐4 in the nude mice tumours