TABLE 1.
The functions of miRNAs in atopic dermatitis
| miRNAs | Mechanism of action | Target cells | Target mRNA |
|---|---|---|---|
| miR‐10a‐5p | Inhibition of keratinocyte proliferation | Epidermal keratinocytes | HAS3 |
| miR‐29b | Promotion of INF‐γ‐induced keratinocyte apoptosis | Epidermal keratinocytes | BCL2L2 |
| miR‐124 | Inhibition of inflammatory responses | Epidermal keratinocytes | RELA (p65 subunit of NF‐κB) |
| miR‐143 | Suppression of IL‐13‐induced dysregulation of skin barrier proteins | Epidermal keratinocytes | IL‐13Rα1 |
| miR‐146a | Suppressing the expression of many pro‐inflammatory factors | Epidermal keratinocytes | IRAK1, CARD10, CCL5 |
| miR‐151a | Inhibition of IL‐12 signalling | T helper cells | IL12RB2 |
| miR‐155 | Promotion of Th17 differentiation | T cells | CTLA‐4 |
| Inhibition of tight junction formation | Epidermal keratinocytes | PKIα | |
| miR‐223 | Positive correlation with Treg cell number | Not specified | Not specified |