TABLE 1.

Technical differences in apical resection operation among laboratories

Reference	Mahmoud et al 10	Andersen et al 6	Bryant et al 11	Xiong and Hou 13	Notari et al 12	This study
Mouse strain	ICR/CD‐1	C57BL/6 & ICR/CD‐1	ICR/CD‐1	C57BL/6	ICR/CD‐1	C57BL/6
Foster mother	Yes	No		Yes	Not mention	No
Anaesthesia time	On the ice bed 3‐5 min	On the ice bed 4 min	On the ice bed 4 min	On the ice bed 4 min	On the ice bed 3‐5 min	On the ice bed 2‐3 min
Stereomicroscope	No	Yes	Yes	No	No	Yes
Thoracotomy	Exteriorize the heart outside the chest cavity by applying a steady pressure on the abdomen	A microsurgical forceps was utilized to gently fix the apex	Gently fixed the left ventricle with a microneedle holder	By hand, gently apply pressure on the abdomen to exteriorize the apex of the heart	Gently lifted the left ventricular apex upwards using a needle inserted above the portion to be resected	The heart was exteriorized with the help of forceps
Survival rate	70%	80%‐85%	70%	60%	80%	90%
Regeneration	Yes	No	Yes	Yes	Yes	Yes
Assessment region	Entire ventricular	Whole heart tissue	3‐5 regions throughout the left ventricular chamber	Entire ventricular	Consecutive serial 5‐um‐thick section spanned throughout the injury area of the heart	Whole heart slice