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. 2020 May 6;24(11):6191–6207. doi: 10.1111/jcmm.15246

TABLE 2.

Pooled and Subgroup analysis of the associations between IL‐6 polymorphisms and CAD risk

Subgroup analysis No. of the studies Allelic genetic model Dominant genetic model Recessive genetic model Heterozygote genetic model Homozygote genetic model
OR [95%CI] P 1/Bon/FDR P 2/I2/EM OR [95%CI] P 1/Bon/FDR P 2/I2/EM OR [95%CI] P 1/Bon/FDR P 2/I2/EM OR [95%CI] P 1/Bon/FDR P 2/I2/EM OR [95%CI] P 1/Bon/FDR P 2/I2/EM
IL6 rs1800795 polymorphism
Pooled results 33 1.40 [1.12, 1.75] .003/.015/.015 2*10−4/93%/R 1.21 [1.05, 1.40] .01/.050/.0167 2*10−4/69%/R 1.34 [1.02, 1.76] .04/.200/.040 2*10−4/78%/R 1.15 [1.01, 1.30] .03/.150/.038 2*10−4/54%/R 1.48 [1.10, 2.00] .01/.050/.017 2*10−4/78%/R
Subgroup Results
HWE
In accordance with HWE 28 1.31 [1.08, 1.59] .007/.035/.035 2*10−4/88%/R 1.18 [1.00, 1.39] .04/.200/.060 2*10−4/69%/R 1.30 [0.99, 1.72] .06/.300/.060 2*10−4/69%/R 1.15 [0.99, 1.32] .06/.300/.060 2*10−4/55%/R 1.40 [1.01, 1.94] .04/.200/.060 2*10−4/75%/R
Departure from HWE 5 1.97 [1.01, 3.85] .05/.25/.20 2*10−4/97%/R 1.34 [0.96, 1.88] .09/.45/.20 .005/73%/R 1.49 [0.65, 3.40] .35/1.00/.41 2*10−4/92%/R 1.14 [0.83, 1.58] .41/1.00/.41 .03/63%/R 1.79 [0.86, 3.74] .12/.60/.20 2*10−4/84%/R
Region
Asian 21 1.84 [1.42, 2.39] 2*10−4/2*10−4/2*10−4 2*10−4/91%/R 1.40 [1.24, 1.58] 2*10−4/2*10−4/2*10−4 .05/36%/R 1.99 [1.63, 2.42] 2*10−4/2*10−4/2*10−4 .20/22%/R 1.26 [1.11, 1.43] 2*10−4/.002/2*10−4 .10/30%/R 2.21 [1.78, 2.73] 2*10−4/2*10−4/2*10−4 .14/28%/R
Europe 7 1.20 [0.87, 1.65] .27/1/.800 2*10−4/90%/R 1.13 [0.80, 1.59] .48/1/.800 2*10−4/82%/R 1.05 [0.65, 1.69] .84/1/.840 2*10−4/81%/R 1.11 [0.85, 1.46] .43/1/.800 .005/67%/R 1.15 [0.62, 2.11] .66/1/.825 2*10−4/86%/R
Africa 3 0.45 [0.26, 0.77] .004/.02/.01 .06/64%/R 0.33 [0.08, 1.33] .12/.60/.15 .009/79%/R 0.29 [0.17, 0.50] 2*10−4/.00/.00 .37/1%/R 0.41 [0.11, 1.58] .20/1.00/.20 .02/74%/R 0.11 [0.01, 1.37] .09/.45/.15 0.009/79%/R
South America 2 0.97 [0.67, 1.41] .88/1/.880 .17/46%/R 0.87 [0.53, 1.43] .58/1/.725 .13/56%/R 1.50 [0.77, 2.91] .23/1/.650 .84/0%/R 0.80 [0.48, 1.33] .39/1/.650 .14/53%/R 1.45 [0.74, 2.85] .28/1/.650 .99/0%/R
Ethnicity
Caucasian 17 1.44 [1.10, 1.90] .009/.045/.045 2*10−4/93%/R 1.20 [0.98, 1.47] .07/.350/.150 2*10−4/73%/R 1.27 [0.89, 1.81] .18/.900/.180 2*10−4/74%/R 1.15 [0.98, 1.37] .09/.450/.150 .003/56%/R 1.40 [0.92, 2.14] .12/.600/.150 2*10−4/79%/R
Mongoloid 12 1.97 [1.44, 2.70] 2*10−4/2*10−4/2*10−4 2*10−4/90%/R 1.47 [1.31, 1.65] 2*10−4/2*10−4/2*10−4 .40/4%/R 2.07 [1.72, 2.50] 2*10−4/2*10−4/2*10−4 .94/0%/R 1.28 [1.11, 1.49] .001/.004/2*10−4 .24/21%/R 2.28 [1.87, 2.77] 2*10−4/2*10−4/2*10−4 .92/0%/R
African 4 0.52 [0.32, 0.86] .01/.05/.050 .01/72%/R 0.49 [0.23, 1.05] .07/.35/.125 .03/66%/R 0.46 [0.18, 1.17] .10/.50/.125 .06/59%/R 0.55 [0.28, 1.11] .10/.50/.125 .08/56%/R 0.24 [0.03, 1.61] .14/.70/.140 .003/79%/R
Source of Controls
Hospital based 25 1.48 [1.14, 1.94] .004/.020/.020 2*10−4/94%/R 1.16 [0.99, 1.35] .07/.350/.088 2*10−4/68%/R 1.46 [1.10, 1.94] .009/.045/.0225 2*10−4 /72%/R 1.10 [0.96, 1.25] .18/.900/.180 .004/48%/R 1.50 [1.08, 2.09] .02/.100/.033 2*10−4/78%/R
Population based 8 1.18 [0.78, 1.80] .43/1.0/.5375 2*10−4/91%/R 1.39 [0.98, 1.96] .06/.3/.200 .001/72%/R 1.17 [0.57, 2.40] .68/1.0/.6800 2*10−4/87%/R 1.34 [0.97, 1.84] .08/.4/.200 .007/64%/R 1.37 [0.64, 2.92] .41/1.0/.538 2*10−4/81%/R
Sample size
Less than 300 14 1.21 [0.68, 2.18] .52/1.0/.97 2*10−4/93%/R 1.05 [0.72, 1.54] .80/1.0/.97 2*10−4/68%/R 1.02 [0.47, 2.21] .97/1.0/.97 2*10−4/79%/R 1.04 [0.77, 1.41] .80/1.0/.97 .03/46%/R 1.04 [0.77, 1.41] .94/1.0/.97 2*10−4/78%/R
Between 300 and 500 7 1.11 [0.80, 1.53] .54/1.0/.99 2*10−4/85%/R 1.05 [0.73, 1.51] .80/1.0/.99 2*10−4/79%/R 0.92 [0.59, 1.43] .71/1.0/.99 .02/61%/R 1.08 [0.76, 1.54] .66/1.0/.99 .001/75%/R 1.08 [0.76, 1.54] .99/1.0/.99 .001/73%/R
More than 500 12 1.81 [1.33, 2.45] 2*10−4/2*10−4/2*10−4 2*10−4/95%/R 1.37 [1.17, 1.59] 2*10−4/2*10−4/2*10−4 .001/64%/R 1.95 [1.42, 2.67] 2*10−4/2*10−4/2*10−4 2*10−4/78%/R 1.22 [1.06, 1.40] .004/2*10−4/.004 .03/48%/R 1.22 [1.06, 1.40] 2*10−4/2*10−4/2*10−4 2*10−4/80%/R
IL6 rs1800796 polymorphism
Pooled results 21 1.28 [1.13, 1.44] 2*10−4/.001/2*10−4 2*10−4/68%/R 1.35 [1.17, 1.57] 2*10−4/.001/2*10−4 2*10−4/62%/R 1.35 [1.18, 1.55] 2*10−4/.001/2*10−4 .01/46%/F 1.26 [1.15, 1.37] 2*10−4/2*10−4/2*10−4 .001/47%/F 1.62 [1.23, 2.13] .001/.003/.001 2*10−4/60%/R
Subgroup results
HWE
In accordance with HWE 14 1.32 [1.15, 1.53] 2*10−4/2*10−4/2*10−4 2*10−4/70%/R 1.42 [1.19, 1.69] 2*10−4/2*10−4/2*10−4 .001/62%/R 1.48 [1.15, 1.91] .002/2*10−4/.0020 .02/50%/R 1.33 [1.14, 1.55] 2*10−4/2*10−4/.001 .02/49%/R 1.78 [1.28, 2.47] .001/2*10−4/.001 .002/60%/R
Departure from HWE 7 1.18 [0.94, 1.47] .15/.75/.283 .01/63%/R 1.22 [0.92, 1.62] .16/.80/.283 .02/60%/R 1.16 [0.84, 1.61] .37/1.00/.370 .21/29%/R 1.20 [0.92, 1.56] .17/.85/.283 .07/48%/R 1.31 [0.82, 2.07] .26/1.00/.325 .06/51%/R
Region
Asian 19 1.30 [1.15, 1.47] 2*10−4/.001/2*10−4 2*10−4/69%/R 1.36 [1.17, 1.58] 2*10−4/.001/2*10−4 2*10−4/63%/R 1.44 [1.16, 1.78] .001/.005/.001 .02/45%/R 1.29 [1.13, 1.48] 2*10−4/.001/2*10−4 .008/50%/R 1.66 [1.26, 2.19] 2*10−4/.002/2*10−4 2*10−4/61%/R
South America a 1 0.83 [0.55, 1.24] .36/1.0/.6375 NA 0.72 [0.27, 1.93] .51/1.0/.638 NA 0.78 [0.46, 1.35] .38/1.0/.638 NA 0.80 [0.29, 2.21] .66/1.0/.660 NA 0.64 [0.23, 1.81] .4/1.0/.638 NA
Europe a 1 1.53 [0.73, 3.19] .26/1.0/.325 NA 8.67 [0.41, 182.13] .16/.8/.325 NA 1.31 [0.60, 2.88] .5/1.0/0.5 NA 7.86 [0.34, 180.34] .2/1.0/.325 NA 8.73 [0.42, 183.62] .16/.8/.325 NA
Ethnicity
Caucasian 16 1.33 [1.17, 1.50] 2*10−4/2*10−4/2*10−4 2*10−4/68%/R 1.38 [1.19, 1.59] 2*10−4/2*10−4/2*10−4 .001/62%/R 1.54 [1.23, 1.93] 2*10−4/2*10−4/2*10−4 .02/47%/R 1.30 [1.14, 1.47] 2*10−4/2*10−4/.0001 .02/46%/R 1.78 [1.34, 2.36] 2*10−4/2*10−4/2*10−4 2*10−4/62%/R
Mongoloid 5 1.02 [0.71, 1.48] .90/1.0/.90 .08/52%/R 1.23 [0.50, 3.04] .65/1.0/.813 .04/61%/R 0.88 [0.63, 1.23] .47/1.0/.813 .82/0%/R 1.31 [0.52, 3.30] .57/1.0/.813 .05/58%/R 0.73 [0.41, 1.31] .30/1.0/.813 .41/0%/R
Source of controls
Hospital based 20 1.30 [1.16, 1.47] 2*10−4/2*10−4/2*10−4 2*10−4/67%/R 1.39 [1.19, 1.61] 2*10−4/2*10−4/2*10−4 2*10−4/61%/R 1.42 [1.16, 1.74] .001/2*10−4/.001 .02/44%/R 1.31 [1.14, 1.50] 2*10−4/2*10−4/.002 .01/47%/R 1.70 [1.29, 2.24] 2*10−4/2*10−4/2*10−4 .001/58%/R
Population based a 1 0.81 [0.56, 1.18] .28/1.0/.5375 NA 0.83 [0.53, 1.31] .43/1.0/.538 NA 0.72 [0.34, 1.53] .39/1.0/.538 NA 0.89 [0.53, 1.50] .67/1.0/.670 NA 0.70 [0.33, 1.51] .37/1.0/.538 NA
Sample size
Less than 300 6 1.46 [0.99, 2.14] .05/.25/.083 .005/71%/R 1.46 [0.99, 2.14] .01/.05/.050 .07/52%/R 1.37 [0.78, 2.40] .28/1.00/.280 .12/42%/R 1.71 [1.06, 2.77] .03/ .15/.075 .06/52%/R 1.75 [0.71, 4.31] .22/1.00/.275 .08/50%/R
Between 300 and 500 5 1.35 [1.01, 1.80] .04/.20/.067 .02/66%/R 1.35 [1.01, 1.80] .04/.20/.067 .04/60%/R 1.56 [0.90, 2.69] .11/.55/.110 .07/54%/R 1.40 [1.07, 1.83] .01/.05/.050 .24/27%/R 2.17 [0.95, 4.93] .06/.30/.075 .01/68%/R
More than 500 10 1.21 [1.05, 1.39] .008/.04/.010 .001/70%/R 1.21 [1.05, 1.39] .01/.05/.013 .006/61%/R 1.36 [1.07, 1.74] .01/.05/.013 .03/50%/R 1.18 [1.03, 1.35] .02/.10/.020 .10/38%/R 1.48 [1.09, 2.01] .01/.05/.013 .002/65%/R

Results with P < .05 even after the Bonferroni adjusted and a tolerable heterogeneity (I2 < 85%) were regarded as significant.

Abbreviations: BMI, body mass index; CI, confidence interval; EM, effect model; F, fixed effect model; OR, odds ratio; P1, P value for meta‐analysis; P2, P value for heterogeneity test; R, random effect model.

a

Only one study was included in the subgroup, and heterogeneity was not applicable.

Results with P < .05 even after the Bonferroni adjusted and a tolerable heterogeneity (I2 < 85%)