Table 2.
Demographical and clinical features of coronary heart disease (CHD) patients and high‐risk controls in validation set‐1 and validation set‐2
Validation set‐1 | Validation set‐2 | |||||
---|---|---|---|---|---|---|
High‐risk control | CHD | P value | High‐risk control | CHD | P value | |
INDV (n = 48) | INDV (n = 48) | INDV (n = 60) | INDV (n = 95) | |||
Age (y) | 53.92 ± 9.02 | 60.92 ± 12.56 | .15 | 165.53 ± 6.48 | 168.05 ± 44.83 | .27 |
Female | 31 | 21 | .18 | 65.02 ± 7.19 | 68.05 ± 19.76 | .24 |
Male | 17 | 27 | .65 | 23.71 ± 1.97 | 24.07 ± 2.47 | .33 |
Clinical features | ||||||
Height (cm) | 165.69 ± 6.68 | 167.87 ± 34.69 | .15 | 165.53 ± 6.48 | 168.05 ± 44.83 | .27 |
Body weight (kg) | 66.11 ± 8.19 | 68.50 ± 16.20 | .18 | 65.02 ± 7.19 | 68.05 ± 19.76 | .24 |
Body mass index | 23.05 ± 2.25 | 24.27 ± 2.33 | .65 | 23.71 ± 1.97 | 24.07 ± 2.47 | .33 |
Blood parameter | ||||||
TCH (mmol/L) | 4.71 ± 1.46 | 4.95 ± 1.72 | .36 | 4.81 ± 1.44 | 4.78 ± 1.46 | .89 |
TG (mmol/L) | 1.61 ± 1.17 | 2.04 ± 1.56 | .15 | 1.583 ± 1.19 | 1.64 ± 0.99 | .76 |
HDL (mmol/L) | 1.31 ± 0.49 | 1.34 ± 0.49 | .66 | 1.34 ± 0.53 | 1.33 ± 0.71 | .91 |
LDL (mmol/L) | 3.04 ± 1.15 | 2.96 ± 1.19 | .77 | 2.94 ± 1.14 | 3.09 ± 1.11 | .39 |
Hcy (μmol/L) | 8.94 ± 5.02 | 10.75 ± 6.52 | .16 | 9.36 ± 5.29 | 10.75 ± 6.16 | .18 |
UA (μmol/L) | 295.71 ± 134.57 | 340.88 ± 144.36 | .14 | 290.73 ± 148.27 | 343.33 ± 153.03 | .03 |
Urea (mmol/L) | 5.32 ± 1.24 | 5.52 ± 1.52 | .5 | 5.23 ± 1.22 | 5.58 ± 1.69 | .19 |
Creatinine (μmol/L) | 65.65 ± 13.64 | 62.10 ± 14.62 | .26 | 62.89 ± 13.12 | 66.39 ± 17.98 | .21 |
Apolipoprotein A (g/L) | 1.34 ± 0.22 | 1.45 ± 0.19 | .02 | 1.34 ± 0.25 | 1.27 ± 0.16 | .09 |
Apolipoprotein B (g/L) | 0.86 ± 0.24 | 0.90 ± 0.29 | .47 | 0.89 ± 0.29 | 5.71 ± 41.93 | .32 |
Lipoprotein(a) (mg/L) | 146.90 ± 130.43 | 197.79 ± 216.11 | .24 | 139.61 ± 127.29 | 198.89 ± 215.23 | .06 |
White blood cell (109/L) | 6.60 ± 1.73 | 6.76 ± 1.51 | .55 | 6.56 ± 1.77 | 6.67 ± 2.12 | .72 |
Lymphocyte (%) | 28.99 ± 7.59 | 27.32 ± 9.38 | .35 | 29.45 ± 8.04 | 32.52 ± 27.05 | .32 |
Neutrophil granulocyte (%) | 61.72 ± 8.88 | 64.12 ± 11.11 | .26 | 61.41 ± 9.17 | 59.92 ± 10.11 | .36 |
Red blood cell (1012/L) | 4.62 ± 0.62 | 4.76 ± 0.69 | .36 | 4.58 ± 0.61 | 4.68 ± 0.51 | .34 |
Hemoglobin (g/L) | 167.78 ± 144.88 | 151.54 ± 15.87 | .45 | 161.79 ± 130.42 | 146.23 ± 14.94 | .38 |
Hematocrit (%) | 41.62 ± 5.35 | 43.78 ± 4.074 | .04 | 48.81 ± 57.99 | 42.36 ± 3.98 | .41 |
Platelet (109/L) | 241.98 ± 68.48 | 216.671 ± 50.41 | .08 | 237.67 ± 66.56 | 220.59 ± 44.74 | .11 |
Other disease | ||||||
Diabetes mellitus, n (%) | 1 (2.08) | 7 (14.58) | 1 (1.67) | 14 (14.74) | ||
Hypertension, n (%) | 12 (25.00) | 18 (37.50) | 15 (25.00) | 43 (45.26) | ||
Cerebral vascular event, n (%) | 0 (0) | 1 (2.08) | 0 (0) | 1 (1.05) | ||
Smoking status, n(%) Angiocardiography results | 7 (14.58) | 13 (27.08) | 6 (10.00) | 27 (28.42) | ||
LM | 1 (slight) | 4 | 1 | 7 | ||
LAD | 14 (slight) | 44 | 22 (slight) | 84 | ||
LCX | 1 (slight) | 32 | 5 | 64 | ||
D | 0 | 5 | 0 | 11 | ||
OM | 0 | 2 | 0 | 4 | ||
RCA | 1 (slight) | 42 | 5 (slight) | 76 | ||
PD | 0 | 0 | 0 | 5 | ||
PL | 0 | 0 | 0 | 3 |
Abbreviations: D, diagonal branch; Hcy, homocysteine; HDL, high‐density lipoprotein; INDV, individual; LAD, left anterior descending; LCX, left circumflex branch; LDL, low‐density lipoprotein; LM, left main coronary artery; OM, obtuse marginal branch; PD, posterior descending branch; PL, posterior branch of left ventricle; RCA, right coronary artery; TCH, total cholesterol; TG, triglycerides; UA, uric acid.