Skip to main content
. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Acta Biomater. 2020 Apr 16;110:68–81. doi: 10.1016/j.actbio.2020.04.013

Figure 5: dECM+PPF as a vascular graft.

Figure 5:

(A) Process of rolling dehydrated dECM, applying PPF, and crosslinking using UV light to create a biohybrid vascular graft (e.g. graft with an inner diameter of 3 mm and 3 cm long as pictured). (B) Circumferential stress (MPa) measured from the rings of the vascular graft and porcine right coronary artery (RCA). The circumferential stress of the graft is comparable to that of RCA, is independent of UV crosslinking time, and increases with degradation (*p=0.010 and **p=0.001; two-sample t-test). (C) Burst pressure (mmHg) measured from the total length of the vascular graft increases between 15 and 45 min UV exposure time. (D) Suture retention strength (N) measured from dECM+PPF and porcine left anterior descending artery (LADA). The suture retention strength of the dECM+PPF demonstrates strengths that are comparable to that of porcine LADA, independent of UV crosslinking time. (E) Fold change of the XTT metabolic activity (normalized to 24 h) as a function of time for HUVECs exposed to dECM with and without PPF. The addition of PPF to dECM does not negatively impact the metabolic activity of cells. Data is shown as mean + standard deviation, except for XTT metabolic fold change where data is mean ± standard deviation.