Fig. 4.

(A) Autoradiography of a representative xenograft tumour sections confirming specific uptake of [¹¹¹In]In-anti-ICAM-1. There is a small increase in uptake of the [¹¹¹In]anti-ICAM-1 antibody compared to the [¹¹¹In]In-mIgG2a negative control conjugate, but little difference in uptake of [¹¹¹In]In-anti-ICAM-1 in xenografts that had been irradiated (IR) compared to mock-treated (MT). (B) Quantification of autoradiography image in (A). (C) Biodistribution quantification (%ID/g) in mice injected with [¹¹¹In]In-anti-ICAM-1 compared to [¹¹¹In]In-mIgG2a, at 72 h post-injection of each IgG molecule. Tumour was either irradiated (IR) or mock treated (MT).