Fig. 3.

Independent validation of the optimised Trovato2020. A) Comparison between the human experimental AP traces from Dataset III (top panels, n = 3) and the simulations with the Trovato2020 model (bottom panels), in control conditions (blue) and with Dofetilide 100 nM (red), at 1 Hz (left) and 2 Hz (right). B) Ability of the model to develop automaticity when no external stimulus (blue asterisks) is applied. Simulations are shown both with normal [K⁺]_o (black) and under hyperkalaemia conditions (light blue), in four different scenarios. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)