Table 1.
Experimental AP biomarkers.
BCL (ms) |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
400 |
500 |
700 |
1000 |
1500 |
2000 |
3000 |
5000 |
|||||||||
Min | Max | Min | Max | Min | Max | Min | Max | Min | Max | Min | Max | Min | Max | Min | Max | |
dV/dtMax (V/s) | 242 | 576 | 176 | 674 | 176 | 644 | 154 | 688 | 195 | 605 | 195 | 625 | 195 | 625 | 151 | 625 |
APD90 (ms) | 167 | 288 | 173 | 338 | 175 | 389 | 187 | 438 | 177 | 445 | 178 | 415 | 179 | 470 | 180 | 497 |
APD75 (ms) | 146 | 253 | 150 | 298 | 151 | 346 | 166 | 384 | 155 | 394 | 157 | 371 | 157 | 421 | 159 | 453 |
APD50 (ms) | 114 | 199 | 118 | 246 | 121 | 292 | 124 | 349 | 122 | 339 | 127 | 292 | 125 | 365 | 129 | 392 |
APD25 (ms) | 32 | 137 | 39 | 148 | 45 | 167 | 31 | 185 | 34 | 209 | 20 | 147 | 19 | 218 | 25 | 226 |
APD10 (ms) | 2 | 65 | 1.4 | 63 | 1 | 82 | 1 | 107 | 1 | 75 | 1 | 23 | 1 | 86 | 1 | 91 |
APA (mV) | 101 | 115 | 101 | 115 | 91 | 115 | 93 | 116 | 93 | 122 | 92 | 115 | 94 | 123 | 89 | 115 |
TOP (mV) | −88 | −80 | −89 | −75 | −90 | −76 | −91 | −79 | −92 | −77 | −87 | −76 | −93 | −77 | −88 | −73 |
EOP (mV) | −91 | −85 | −89 | −79 | −90 | −75 | −94 | −81 | −93 | −77 | −89 | −77 | −93 | −77 | −88 | −72 |
Minimum and maximum experimental values for the 9 AP biomarkers recorded in human cardiac Purkinje cells at multiple BCL: 400 ms (n = 7), 500 ms (n = 7), 700 ms (n = 9), 1000 (n = 17), 1500 ms (n = 9), 2000 ms (n = 7), 3000 (n = 8), 5000 ms (n = 8).
BCL: Basic cycle length; dV/dtMAX: maximum upstroke velocity; APDx: AP duration at X% of repolarisation; APA: action potential amplitude; TOP: membrane potential before depolarisation; EOP: membrane potential at the end of repolarisation.