Table 2.
Simulated and experimental AP biomarkers.
| Experiments | Initial model | Optimised model | |
|---|---|---|---|
| dV/dtMax (V/s) | 387 ± 143 | 435 | 381 |
| APD90 (ms) | 294 ± 76 | 249 | 306 |
| APD75 (ms) | 261 ± 67 | 225 | 279 |
| APD50 (ms) | 210 ± 52 | 168 | 223 |
| APD25 (ms) | 117 ± 46 | 116 | 142 |
| APD10 (ms) | 33 ± 35 | 49 | 34 |
| APA (mV) | 106 ± 7 | 113 | 110 |
| TOP (mV) | −85 ± 2.4 | −86.7 | −86.5 |
| EOP (mV) | −86 ± 2 | −87.2 | −87.3 |
Comparison between experimental and simulated AP biomarkers using the initial and optimised models at 1 Hz (mean ± std).
dV/dtMAX: maximum upstroke velocity; APDx: AP duration at X% of repolarisation; APA: action potential amplitude; TOP: membrane potential before depolarisation; EOP: membrane potential at the end of repolarisation.