Fig. 1.

“Disease evolution map” (DEM) (right) is produced by subtracting baseline images (middle) from follow-up image (left). In DEM produced by irregularity map (IM) (first row) and probability map (PM) (second row), bright yellow pixels represent positive values (i.e., progression) while dark blue pixels represent negative values (i.e., regression). On the other hand, DEM produced by binary WMH label (LBL) (third row) has three foreground labels which represent progression or “Grow” (green), regression or “Shrink” (red), and “Stable” (blue). We named this special DEM as three-class DEM label (LBL-DEM). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)