Fig. 2.

Schematic of the proposed DEP-GAN with 2 discriminators (critics). M(x) is a generator which generates “fake” disease evolution map (DEM) while C(x) and D(x) are critics to enforce anatomically realistic modifications to the follow-up images and encode realistically plausible DEMs. The flows of “fake” images are shown by the dashed lines. DEP-GAN can take either irregularity map (IM) or probability map (PM) as input. DEP-GAN also has an auxiliary input to deal with the non-deterministic factors in WMH evolution (see Section 2.3 for full explanation).