Fig. 3.

β-Amyloid-induced oscillatory increases in calcium-sensing receptor (CaSR)-transfected cells. A: representative traces showing changes in [Ca²⁺]_cyt in control (left), green fluorescent protein (GFP)-transfected (middle), and CASR-transfected (right) human embryonic kidney 293 (HEK293) cells before, during, and after extracellular application of 10 μM β-amyloid in the presence or absence (0 Ca) of 1.8 mM extracellular Ca²⁺. B and C: summarized data (means ± SE) showing the amplitude (B) and frequency (C) of β-amyloid-induced oscillatory increases in [Ca²⁺]_cyt in the presence (red) or absence (0 Ca; blue) of 1.8 mM extracellular Ca²⁺ in HEK293 cells transfected with CASR constructs; n = 5 cells for each group. ***P < 0.001 vs. 0 Ca (ANOVA and Student’s t test).