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Knockdown of cubilin, megalin, and disabled-2 (Dab2) differentially affect albumin uptake via high- and low-affinity pathways. The average (black) curves and individual components (C1, red; C2, green; and C3, blue) obtained by fitting the average kinetic profiles of albumin uptake in control (A), cubilin siRNA (B), megalin siRNA (C), and Dab2 siRNA (D) data sets are plotted. AU, arbitrary units.
