Table 5.

Glomerular parameters in mice treated with 4 wk of DOCA + salt + uninephrectomy + norepinephrine

Parameter	Plce1+/+	Plce1−/−
Number of mice/group	7	5
Sclerotic glomeruli, %	0 ± 0	2.30 ± 1.07*
Mesangial index, %	7.1 ± 1.0	8.0 ± 4.6
Podocytes/glomerulus	76.0 ± 3.2	78.0 ± 1.7
Individual podocyte volume, µm3	1,629 ± 98	1,699 ± 143
Glomerular volume, µm3	240,022 ± 7,257	252,218 ± 11,126

Data are presented as means ± SE. More sclerotic glomeruli were noted after 4 wk of treatment in phospholipase C-ε1 (Plce1)^−/− mice. No other significant differences were noted.

^*P < 0.05 vs. Plce1^+/+ mice.