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. 2020 Mar 16;318(5):F1122–F1135. doi: 10.1152/ajprenal.00606.2019

Fig. 6.

Fig. 6.

ELA-32 treatment inhibits the activation of intrarenal renin-angiotensin system in high salt (HS)-loaded Dahl salt-sensitive (SS) rats. A: representative immunoblotting and densitometric analysis of renal (pro)renin receptor (PRR) and cyclooxygenase-2 (COX-2) expression in different experimental groups; expression was normalized by β-actin. B: quantitative RT-PCR analysis of PRR, renin, AGT, ACE, AT1R, AT2R, and ACE2 mRNA expression in the kidney cortical and medullary; expression was normalized by GAPDH. C: urinary and plasma soluble PRR (sPRR) levels. D: urinary and plasma prorenin/renin levels. E: urinary and plasma angiotensinogen (AGT) levels. F: urinary and plasma angiotensin II (ANG II) levels. Male Dahl SS rats were used in these studies. n = 5 Rats per group. Data are means ± SE. *P < 0.05, **P < 0.01, ***P < 0.001 vs. normal Na+ (NS); #P < 0.05, ##P < 0.01, ###P < 0.001 vs. HS. Statistical analysis was performed by using 1-way analysis of variance with the Bonferroni test using IBM SPSS 19 software. ELA, ELABELA; fPRR, full-length PRR.