Skip to main content
. 2020 Mar 9;318(5):F1074–F1085. doi: 10.1152/ajprenal.00598.2019

Fig. 1.

Fig. 1.

Anti-dsDNA IgG is increased by 28 wk of age in female mice with systemic lupus erythematosus (SLE). A: anti-dsDNA IgG was increased at 34 wk of age (*P = 0.0234) compared with 15 wk of age in female control mice. B: anti-dsDNA IgG was significantly increased by 28 wk of age (*P = 0.0436), 31 wk of age (*P = 0.0012), and 34 wk of age (*P = 0.0032) compared with 15 wk of age in female mice with SLE (95% confidence interval: −258.5 to −2.428, −293.1 to −54.64, and −283 to −41.67, respectively). Anti-dsDNA IgG was significantly increased by 28 wk of age (#P = 0.0072), 31 wk of age (#P = 0.0002), and 34 wk of age (#P = 0.0016) compared with age-matched control mice (95% confidence interval: −208.5 to −22.14, −243.2 to −54.9, and −211.6 to −35.01, respectively). C: representative histograms from control and SLE mice at 20, 28, and 34 wk of age. Peripheral blood leukocytes were isolated and stained with anti-mouse CD45R PE-Cy7. D and E: quantitative representation of CD45R+ B cells at 20, 28, and 34 wk of age in control (D) and SLE (E) mice. E: the percentage of circulating CD45R+ B cells was increased by 34 wk of age (*P = 0.0030) compared with 20 wk in SLE mice (95% CI: −24.24 to −5.204). The percentage of circulating CD45R+ B cells was increased by 28 wk of age (#P = 0.0310) and 34 wk of age (#P < 0.0001) in female mice with SLE compared with age-matched controls (95% confidence interval: −16.35 to −0.6109 and −22.07 to −8.883, respectively). The percentage of CD45R+ B cells did not change in female control mice.