Fig. 8.

Phosphorylation of nitric oxide synthase (NOS3) at serine residue 1177 [pNOS3(Ser¹¹⁷⁷) to total NOS3] over time in female mice. A: phosphorylation of NOS3 at serine residue 1177 was not changed in control mice. B: phosphorylation of NOS3 at serine residue 1177 was lower in female mice with systemic lupus erythematosus (SLE). Phosphorylation of NOS3 at serine residue 1177 was significantly lower at 34 wk of age (*P = 0.0440) in female mice with SLE compared with age-matched control mice (95% confidence interval: 0.03876 to 3.489). C: representative blots for phosphorylation of NOS3 at serine residue 1177 and total NOS3. IC, internal control.