Table 1.
Results of the analysis of stool specimens from patients.
Patient 1 | Patient 2 | |
---|---|---|
Pre-transplant |
Clostridium difficile-negative Candida albicans Enterococcus faecalis (S) |
Clostridium difficile-negative Enterococcus faecium (S) Enterococcus faecalis HLGR |
Post-transplant GvHD |
Clostridium difficile-negative Candida albicans (S) Klebsiella pneumoniae (ESBL+) Enterococcus faecalis (S) Escherichia coli ESBL+ |
C. difficile-negative Enterobacter cloacae ESBL+ Klebsiella pneumoniae (S) Candida albicans (S), Candida parapsilosis (S-voriconazole, R-fluconazole, anidulafungin) |
Post 1st FMT |
Escherichia coli (S) Klebsiella pneumoniae MDR Candida albicans |
Enterococcus faecium HLGR Candida albicans (S) Candida parapsilosis (S – voriconazole, R – fluconazole, anidulafungin) Stenotrophomonas maltophilia (S – trimethoprim/ sulfamethoxazole), Klebsiella pneumoniae (S) |
Post 2nd FMT |
Enterococcus faecium GRE*** Klebsiella pneumoniae PDR**** Acinetobacter baumannii MDR***** Candida albicans |
Stenotrophomonas maltophilia
(S- trimethoprim/ sulfamethoxazole) Enterococcus faecium VRE Candida albicans |
Post 3rd FMT |
Klebsiella pneumoniae (S) Candida albicans (S) Acinetobacter baumannii MDR***** |
Escherichia coli ESBL+ Enterococcus faecium VRE Candida albicans |
Post 4th FMT | Not done |
Escherichia coli (S) Citrobacter freundii (S) |
FMT, fecal microbiota transplantation; S, susceptible to all tested antibiotics; R, resistant to at least one of the tested drugs; GvHD, graft-versus host disease, ESBL+, extended-spectrum beta-lactamase positive; MDR, multidrug-resistant; PDR, pan-drug-resistant; HLGR, high-level aminoglycoside-resistant
E. coli ESBL+ *(S – netilmicin, meropenem, ertapenem, piperacillin/tazobactam, gentamicin, amikacin; R – ciprofloxacin, cefuroxime, ceftazidime, ampicillin/sulbactam, levofloxacin, trimethoprim/sulfamethoxazole), Klebsiella pneumoniae MDR** – all, S – colistin, imipenem, tigecycline), Enterococcus faecium GRE*** (R – ampicillin, imipenem, vancomycin, teicoplanin, gentamicin, S – linezolid), Klebsiella pneumoniae PDR* (R – all, S – colistin), Enterococcus faecium HLGR (S – vancomycin, teicoplanin, linezolid, R – ampicillin, imipenem, gentamicin), Acinetobacter baumannii MDR***** – all, S – colistin, tobramycin), Enterobacter cloacae ESBL+ (R – all, S – meropenem, ertapenem, imipenem, colistin).